Gene

myrf

ID
ZDB-GENE-080204-57
Name
myelin regulatory factor
Symbol
myrf Nomenclature History
Previous Names
  • c11orf9 (1)
  • zgc:172183
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in central nervous system myelin maintenance; positive regulation of transcription, DNA-templated; and protein autoprocessing. Predicted to localize to endoplasmic reticulum membrane and nucleus. Used to study eye disease. Orthologous to human MYRF (myelin regulatory factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myrf Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cardiac-urogenital syndrome 618280
Encephalitis/encephalopathy, mild, with reversible myelin vacuolization 618113
Associated With myrf Via Experimental Models
Human Disease Fish Conditions Citations
eye disease AB + MO1-myrf standard conditions Xiao et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR024061 NDT80 DNA-binding domain
Domain IPR025719 Myelin gene regulatory factor C-terminal domain 2
Domain IPR026932 Myelin gene regulatory factor, ICA domain
Domain IPR030392 Intramolecular chaperone auto-processing domain
Family IPR051577 Myelin Regulatory Factor-like
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR037141 NDT80 DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Intramolecular chaperone auto-processing domain Myelin gene regulatory factor C-terminal domain 2 Myelin gene regulatory factor, ICA domain Myelin Regulatory Factor-like NDT80 DNA-binding domain NDT80 DNA-binding domain superfamily p53-like transcription factor, DNA-binding domain superfamily
UniProtKB:A0A8M3ANV6 1027
UniProtKB:A0A8M9P6L9 1009
UniProtKB:A0A8M9PV81 1034
UniProtKB:A0A8M9PYN2 1036
UniProtKB:A0A8M3AWA7 1037
UniProtKB:A0A8M9PH29 1008
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA myrf-201 (1) Ensembl 4,844 nt
mRNA myrf-202 (1) Ensembl 2,051 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations