Gene
kif22
- ID
- ZDB-GENE-080204-34
- Name
- kinesin family member 22
- Symbol
- kif22 Nomenclature History
- Previous Names
-
- zKIF22 (1)
- zgc:171724
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including central nervous system development; somitogenesis; and thigmotaxis. Predicted to be located in cytoskeleton and nucleus. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in brain. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Blaker-Lee et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia with joint laxity type 2 | Alliance | Spondyloepimetaphyseal dysplasia with joint laxity, type 2 | 603546 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR010994 | RuvA domain 2-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase | RuvA domain 2-like |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WFU8 | InterPro | 634 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-149K17 | ||
| Encodes | cDNA | MGC:171724 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198215 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198219 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113591 (1) | 2316 nt | ||
| Genomic | GenBank:AL929469 (1) | 146415 nt | ||
| Polypeptide | UniProtKB:A8WFU8 (1) | 634 aa |
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Beaudoin, J.D., Novoa, E.M., Vejnar, C.E., Yartseva, V., Takacs, C.M., Kellis, M., Giraldez, A.J. (2018) Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Nature structural & molecular biology. 25(8):677-686
- McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712
- Rodriguez, R.S., Haugen, R., Rueber, A., Huang, C.C. (2014) Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 163:47-54
- Blaker-Lee, A., Gupta, S., McCammon, J.M., De Rienzo, G., and Sive, H. (2012) Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Disease models & mechanisms. 5(6):834-851
- Wang, H. (2010) Characterization of zebrafish Esrom (Myc-binding protein 2) RCC1-like domain splice variants. Molecular and cellular biochemistry. 339(1-2):191-199
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 7 of 7
Show