ZFIN ID: ZDB-GENE-080204-107
Gene Name: colony stimulating factor 1a (macrophage)
Gene Symbol: csf1a    Nomenclature History

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Previous Names: csf1-1 (1), mcsf1 (1), zgc:172186 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have cytokine activity. Predicted to localize to extracellular space. Is expressed in integument and iridophore. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).
Genome Resources: Alliance (1),  Gene:100004617 (1),  Ensembl(GRCz11):ENSDARG00000075343 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 5 publications
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hkz9 Insertion Unknown Unknown CRISPR
re05 Indel Unknown Unknown CRISPR
sa10048 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11338 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21898 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21899 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-csf1a 1
    CRISPR2-csf1a 1
    DISEASE ASSOCIATED WITH csf1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH csf1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA csf1a-201 (1)    Ensembl 2441
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM csf1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-9.1-csf1a:mCherry,myl7:EGFP) csf1amyl7 EGFPmCherry Danio rerio 1 1
    Tg(hsp70l:csf1a,NLS-CFP) hsp70l CFPcsf1a Danio rerio 1 5
    Tg(hsp70l:kitlga,csf1a,NLS-CFP) hsp70l csf1akitlga Danio rerio 1 2
    Tg(Xla.Tubb:csf1a) csf1a Danio rerioXenopus laevis 1 1
    Tg1(-9.1csf1a:mCherry,myl7:EGFP) csf1amyl7 EGFPmCherry Danio rerio 1 1
    Tg2(-9.1-csf1a:mCherry,myl7:EGFP) csf1amyl7 EGFPmCherry Danio rerio 1 1
    Tg3(-9.1-csf1a:mCherry,myl7:EGFP) csf1amyl7 EGFPmCherry Danio rerio 1 1
    Tg4(-9.1-csf1a:mCherry,myl7:EGFP) csf1amyl7 EGFPmCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    csf1a Contained in: [BAC] DKEY-235D17 (1) (order this), DKEY-262K23 (1) (order this)
    csf1a Encodes: [cDNA] MGC:172186 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001114480 (1) 2366 nt
    Genomic GenBank:BX571675 (1) 207497 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A9JRD6 (1) 526 aa
    Sequence Information (all 16)
    ORTHOLOGY for csf1a ( Chr: 11 )
    CITATIONS (34)