Gene
il21r.1
- ID
- ZDB-GENE-080108-6
- Name
- interleukin 21 receptor, tandem duplicate 1
- Symbol
- il21r.1 Nomenclature History
- Previous Names
-
- il-21ra.a (1)
- il21r
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in B-cell lymphoma (multiple); Crohn's disease; autoimmune disease (multiple); human immunodeficiency virus infectious disease; and immunodeficiency 56. Orthologous to human IL21R (interleukin 21 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa33294 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
immunodeficiency 56 | Alliance | Immunodeficiency 56 | 615207 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Fibronectin type III superfamily | Immunoglobulin-like fold |
---|---|---|---|---|
UniProtKB:A8WH85 | InterPro | 508 | ||
UniProtKB:X1WC58 | InterPro | 523 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
il21r.1-201
(1)
|
Ensembl | 2,398 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-235I8 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001113510 (1) | 2301 nt | ||
Genomic | GenBank:CT573452 (2) | 149560 nt | ||
Polypeptide | UniProtKB:X1WC58 (1) | 523 aa |
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Yuan, Y., Zhang, J., Zhou, Q. (2016) Overexpression of Jak1 Activating Mutants in Hepatocytes Is Insufficient to Generate Hepatocellular Carcinoma in Zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 43:99-102
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
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