Gene
dock1
- ID
- ZDB-GENE-080108-5
- Name
- dedicator of cytokinesis 1
- Symbol
- dock1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within myelination of posterior lateral line nerve axons; myoblast fusion; and peripheral nervous system myelin maintenance. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human DOCK1 (dedicator of cytokinesis 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR027007 | C2 DOCK-type domain |
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR032376 | Dedicator of cytokinesis, N-terminal domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Domain | IPR047025 | Dedicator of cytokinesis protein 1/5, SH3 domain |
| Domain | IPR047026 | Dedicator of cytokinesis protein 1, C2 domain |
| Domain | IPR056372 | Dedicator of cytokinesis, TPR repeats region |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR042455 | Dedicator of cytokinesis, N-terminal, subdomain 1 |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | Dedicator of cytokinesis, N-terminal domain | Dedicator of cytokinesis, N-terminal, subdomain 1 | Dedicator of cytokinesis protein 1/5, SH3 domain | Dedicator of cytokinesis protein 1, C2 domain | Dedicator of cytokinesis, TPR repeats region | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8E1V6 | InterPro | 1866 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available