Gene
il2rb
- ID
- ZDB-GENE-080108-2
- Name
- interleukin 2 receptor, beta
- Symbol
- il2rb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immunoglobulin mediated immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in head kidney. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 63 | Alliance | Immunodeficiency 63 with lymphoproliferation and autoimmunity | 618495 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003531 | Short hematopoietin receptor, family 1, conserved site |
| Domain | IPR040951 | Interleukin-2 receptor subunit beta, N-terminal |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III superfamily | Immunoglobulin-like fold | Interleukin-2 receptor subunit beta, N-terminal | Short hematopoietin receptor, family 1, conserved site |
|---|---|---|---|---|---|---|
| UniProtKB:A8WH92 | InterPro | 503 | ||||
| UniProtKB:A0A8M2BIX1 | InterPro | 541 | ||||
| UniProtKB:A0AB32TD91 | InterPro | 442 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-156N19 | ||
| Contained in | BAC | CH211-256M1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-226A5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128267 (1) | 1512 nt | ||
| Genomic | GenBank:BX085195 (1) | 227111 nt | ||
| Polypeptide | UniProtKB:A0A8M2BIX1 (1) | 541 aa |
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Lin, C., Tang, Y., Wang, Y., Zhang, J., Li, Y., Xu, S., Xia, B., Zhai, Q., Li, Y., Zhang, L., Liu, J. (2022) WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish. Microbiology spectrum. 10(2):e0044321
- Jedrychowska, J., Gasanov, E.V., Korzh, V. (2020) Kcnb1 plays a role in development of the inner ear. Developmental Biology. 471:65-75
- Lv, P., Ma, D., Gao, S., Zhang, Y., Bae, Y.K., Liang, G., Gao, S., Choi, J.H., Kim, C.H., Wang, L., Liu, F. (2020) Generation of foxn1/Casper Mutant Zebrafish for Allograft and Xenograft of Normal and Malignant Cells. Stem Cell Reports. 15(3):749-760
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Zhu, L.Y., Pan, P.P., Fang, W., Shao, J.Z., and Xiang, L.X. (2012) Essential Role of IL-4 and IL-4Ralpha Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates. Journal of immunology (Baltimore, Md. : 1950). 188(11):5571-5584
- Wang, T., Huang, W., Costa, M.M., Martin, S.A., and Secombes, C.J. (2011) Two copies of the genes encoding the subunits of putative interleukin (IL)-4/IL-13 receptors, IL-4Rα, IL-13Rα1 and IL-13Rα2, have been identified in rainbow trout (Oncorhynchus mykiss) and have complex patterns of expression and modulation. Immunogenetics. 63(4):235-253
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