ZFIN is now using GRCz12tu for Genomic Data
Gene
lifrb
- ID
- ZDB-GENE-080107-2
- Name
- LIF receptor subunit alpha b
- Symbol
- lifrb Nomenclature History
- Previous Names
-
- si:dkey-120e24.3
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be located in plasma membrane. Is expressed in several structures, including immune system; liver; nervous system; notochord; and otic vesicle. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Hanington et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Stuve-Wiedemann syndrome/Schwartz-Jampel type 2 syndrome | 601559 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003529 | Long hematopoietin receptor, Gp130 family 2, conserved site |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR040817 | Leukemia inhibitory factor receptor, D2 domain |
| Family | IPR052672 | Type I Cytokine Receptor Family, Type 2 Subfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Leukemia inhibitory factor receptor, D2 domain | Long hematopoietin receptor, Gp130 family 2, conserved site | Type I Cytokine Receptor Family, Type 2 Subfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5F5 | InterPro | 960 | ||||||
| UniProtKB:A8WH83 | InterPro | 956 | ||||||
| UniProtKB:A0ACD6B615 | InterPro | 960 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers