Gene
tbx21
- ID
- ZDB-GENE-080104-3
- Name
- T-box transcription factor 21
- Symbol
- tbx21 Nomenclature History
- Previous Names
-
- T-bet (2)
- tbx21l
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification; lymphocyte migration; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including digestive system; hematopoietic system; integument; kidney; and telencephalon. Human ortholog(s) of this gene implicated in asthma, nasal polyps, and aspirin intolerance and immunodeficiency 88. Orthologous to human TBX21 (T-box transcription factor 21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tbx21 | (2) | |
| CRISPR2-tbx21 | (2) | |
| CRISPR3-tbx21 | (2) | |
| CRISPR4-tbx21 | (2) | |
| CRISPR5-tbx21 | (2) | |
| CRISPR6-tbx21 | (2) | |
| CRISPR7-tbx21 | (2) | |
| CRISPR8-tbx21 | (2) | |
| CRISPR9-tbx21 | (2) | |
| CRISPR10-tbx21 | (2) |
1 - 10 of 13
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| asthma, nasal polyps, and aspirin intolerance | Alliance | Asthma and nasal polyps | 208550 |
| asthma, nasal polyps, and aspirin intolerance | Alliance | {Asthma, aspirin-induced, susceptibility to} | 208550 |
| immunodeficiency 88 | Alliance | ?Immunodeficiency 88 | 619630 |
1 - 3 of 3
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR032385 | T-box transcription factor-associated |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor-associated | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:D1YT98 | InterPro | 609 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(tbx21:GAL4FF) |
|
| 1 | Miyasaka et al., 2014 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194K22 |
1 - 1 of 1
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001170599 (1) | 2467 nt | ||
| Genomic | GenBank:BX248092 (1) | 217001 nt | ||
| Polypeptide | UniProtKB:D1YT98 (1) | 609 aa |
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Kumar, J., Kumar, M., Sharma, S., Srivastava, N., Singh, R., Hussain, M.A., Mazumder, S. (2022) Th1-Th2 and M1-M2 interplay sculpt Aeromonas hydrophila pathogenesis in zebrafish (Danio rerio). Fish & shellfish immunology. 127:357-365
- Talbot, C.D., Walsh, M.D., Cutty, S.J., Elsayed, R., Vlachaki, E., Bruce, A.E.E., Wardle, F.C., Nelson, A.C. (2022) Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Frontiers in cell and developmental biology. 10:982477
- Farr, D.A., Nag, D., Withey, J.H. (2021) Characterization of the Immune Response to Vibrio cholerae Infection in a Natural Host Model. Frontiers in cellular and infection microbiology. 11:722520
- Chen, W., Bian, C., You, X., Li, J., Ye, L., Wen, Z., Lv, Y., Zhang, X., Xu, J., Yang, S., Gu, R., Lin, X., Shi, Q. (2019) Genome Sequencing of the Japanese Eel (Anguilla japonica) for Comparative Genomic Studies on tbx4 and a tbx4 Gene Cluster in Teleost Fishes. Marine drugs. 17(7)
- Giallongo, C., Tibullo, D., Camiolo, G., Parrinello, N.L., Romano, A., Puglisi, F., Barbato, A., Conticello, C., Lupo, G., Anfuso, C.D., Lazzarino, G., Li Volti, G., Palumbo, G.A., Di Raimono, F. (2019) TLR4 signaling drives mesenchymal stromal cells commitment to promote tumor microenvironment transformation in multiple myeloma. Cell Death & Disease. 10:704
- Shi, W., Shao, T., Li, J.Y., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 203(9):2425-2442
- Harjula, S.E., Ojanen, M.J.T., Taavitsainen, S., Nykter, M., Rämet, M. (2018) Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection. Scientific Reports. 8:10360
- Jensen, H.M., Korbut, R., Kania, P.W., Buchmann, K. (2018) Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio). PLoS One. 13:e0200016
- Myllymäki, H., Niskanen, M., Luukinen, H., Parikka, M., Rämet, M. (2018) Identification of protective postexposure mycobacterial vaccine antigens using an immunosuppression-based reactivation model in the zebrafish. Disease models & mechanisms. 11(3)
1 - 10 of 37
Show