Gene

dnajc6

ID

ZDB-GENE-080104-2

Name

DnaJ (Hsp40) homolog, subfamily C, member 6

Symbol

dnajc6 Nomenclature History

Previous Names

Aux (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have clathrin binding activity. Predicted to be involved in clathrin coat disassembly and clathrin-dependent endocytosis. Localizes to cytosol and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Is expressed in hindbrain; inner ear; neural rod; otic vesicle; and spinal cord. Orthologous to human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Bai et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnajc6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Parkinson's disease 19A	Alliance	Parkinson disease 19a, juvenile-onset	615528
Parkinson's disease 19A	Alliance	Parkinson disease 19b, early-onset	615528

Associated With dnajc6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001623	DnaJ domain
Domain	IPR014020	Tensin phosphatase, C2 domain
Domain	IPR029023	Tensin-type phosphatase domain
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036869	Chaperone J-domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain superfamily	Chaperone J-domain superfamily	DnaJ domain	Protein-tyrosine phosphatase-like	Tensin phosphatase, C2 domain	Tensin-type phosphatase domain
UniProtKB:A0A8M9Q0M0 InterPro	917
UniProtKB:A0A8M9PF24 InterPro	742
UniProtKB:A0A8M9Q4I9 InterPro	748
UniProtKB:A0A8M9QG43 InterPro	974
UniProtKB:A0A8M9Q219 InterPro	764
UniProtKB:A0A8M9QB30 InterPro	954
UniProtKB:A0A8M9Q6X2 InterPro	979
UniProtKB:A0A8M3B0J3 InterPro	970
UniProtKB:A0A8M9PRW9 InterPro	773
UniProtKB:A0A8M9PRF3 InterPro	773
UniProtKB:A0A8M9PMW6 InterPro	948
UniProtKB:A0A8M9PY08 InterPro	764
UniProtKB:A0A8M9P987 InterPro	742
UniProtKB:A0A8M9PYN9 InterPro	748

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnajc6-201 (1) Ensembl	Ensembl	7,250 nt	Select Tool
mRNA	dnajc6-203 (1) Ensembl	Ensembl	2,673 nt	Select Tool ZFIN BLAST
mRNA	dnajc6-204 (1) Ensembl	Ensembl	2,616 nt	Select Tool ZFIN BLAST
mRNA	dnajc6-205 (1) Ensembl	Ensembl	2,700 nt	Select Tool ZFIN BLAST
mRNA	dnajc6-206 (1) Ensembl	Ensembl	2,604 nt	Select Tool ZFIN BLAST
mRNA	dnajc6-207 (1) Ensembl	Ensembl	2,649 nt	Select Tool ZFIN BLAST
mRNA	dnajc6-208 (1) Ensembl	Ensembl	2,613 nt	Select Tool ZFIN BLAST
mRNA	dnajc6-209 (1) Ensembl	Ensembl	2,742 nt	Select Tool ZFIN BLAST
ncRNA	dnajc6-002 (1) Ensembl	Ensembl	560 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations