Gene
tead3b
- ID
- ZDB-GENE-080103-3
- Name
- TEA domain family member 3 b
- Symbol
- tead3b Nomenclature History
- Previous Names
-
- tead-3b (1)
- tead3l
- zgc:171784
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic organ development; hippo signaling; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human TEAD3 (TEA domain transcription factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tead3b | Buono et al., 2021 | |
| CRISPR2-tead3b | Buono et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000818 | TEA/ATTS domain |
| Domain | IPR041086 | YAP binding domain |
| Family | IPR016361 | Transcriptional enhancer factor, metazoa |
| Family | IPR027253 | Transcriptional enhancer factor TEF-5 (TEAD3) |
| Family | IPR050937 | TEC1/TEAD Transcription Factor |
| Homologous_superfamily | IPR038096 | TEA/ATTS domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | TEA/ATTS domain | TEA/ATTS domain superfamily | TEC1/TEAD Transcription Factor | Transcriptional enhancer factor, metazoa | Transcriptional enhancer factor TEF-5 (TEAD3) | YAP binding domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BDI0 | InterPro | 425 | ||||||
| UniProtKB:A0A8M2BDL1 | InterPro | 406 | ||||||
| UniProtKB:A0A8M2BDM4 | InterPro | 425 | ||||||
| UniProtKB:A0A8M2BDI4 | InterPro | 402 | ||||||
| UniProtKB:A0A8M2BDJ0 | InterPro | 421 | ||||||
| UniProtKB:A0A8M2BDQ4 | InterPro | 421 | ||||||
| UniProtKB:A7MBZ7 | InterPro | 402 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tead3b-201
(1)
|
Ensembl | 1,820 nt | ||
| mRNA |
tead3b-202
(1)
|
Ensembl | 817 nt | ||
| mRNA |
tead3b-203
(1)
|
Ensembl | 784 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-38E6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-70O1 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171784 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001109724 (1) | 1837 nt | ||
| Genomic | GenBank:CR847929 (1) | 198536 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDI0 (1) | 425 aa |
- Buono, L., Corbacho, J., Naranjo, S., Almuedo-Castillo, M., Moreno-Marmol, T., de la Cerda, B., Sanbria-Reinoso, E., Polvillo, R., Díaz-Corrales, F.J., Bogdanovic, O., Bovolenta, P., Martínez-Morales, J.R. (2021) Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish. Nature communications. 12:3866
- Xue, C., Liu, X., Wen, B., Yang, R., Gao, S., Tao, J., Zhou, J. (2019) Zebrafish Vestigial Like Family Member 4b Is Required for Valvulogenesis Through Sequestration of Transcription Factor Myocyte Enhancer Factor 2c. Frontiers in cell and developmental biology. 7:277
- Nudelman, G., Frasca, A., Kent, B., Sadler, K.C., Sealfon, S.C., Walsh, M.J., Zaslavsky, E. (2018) High resolution annotation of zebrafish transcriptome using long-read sequencing. Genome research. 28(9):1415-1425
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Grampa, V., Delous, M., Zaidan, M., Odye, G., Thomas, S., Elkhartoufi, N., Filhol, E., Niel, O., Silbermann, F., Lebreton, C., Collardeau-Frachon, S., Rouvet, I., Alessandri, J.L., Devisme, L., Dieux-Coeslier, A., Cordier, M.P., Capri, Y., Khung-Savatovsky, S., Sigaudy, S., Salomon, R., Antignac, C., Gubler, M.C., Benmerah, A., Terzi, F., Attié-Bitach, T., Jeanpierre, C., Saunier, S. (2016) Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. PLoS Genetics. 12:e1005894
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mann, C.J., Osborn, D.P., and Hughes, S.M. (2007) Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord. Gene expression patterns : GEP. 7(8):827-836
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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