Gene
itgb8
- ID
- ZDB-GENE-071213-3
- Name
- integrin, beta 8
- Symbol
- itgb8 Nomenclature History
- Previous Names
-
- si:ch1073-83d9.2
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Acts upstream of or within angiogenesis and endothelial cell proliferation. Predicted to be located in plasma membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in head. Orthologous to human ITGB8 (integrin subunit beta 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Liu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-itgb8 | N/A | (2) |
| MO2-itgb8 | N/A | Liu et al., 2012 |
| MO3-itgb8 | N/A | Hirota et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | EGF-like domain, extracellular | Integrin beta subunit | Integrin beta subunit, tail | Integrin beta subunit, VWA domain | Integrin beta tail domain superfamily | Integrin domain superfamily | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PB88
|
719 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-100F5 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-83D9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021468203 (1) | 2644 nt | ||
| Genomic | GenBank:CU628005 (2) | 35903 nt | ||
| Polypeptide | UniProtKB:A0A8M9PB88 (1) | 719 aa |
- Yamaguchi, N., Zhang, Z., Schneider, T., Wang, B., Panozzo, D., Knaut, H. (2022) Rear traction forces drive adherent tissue migration in vivo. Nature cell biology. 24:194-204
- Krall, M., Htun, S., Anand, D., Hart, D., Lachke, S.A., Slavotinek, A.M. (2018) A zebrafish model of foxe3 deficiency demonstrates lens and eye defects with dysregulation of key genes involved in cataract formation in humans. Human genetics. 137(4):315-328
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hirota, S., Clements, T.P., Tang, L.K., Morales, J.E., Lee, H.S., Oh, S.P., Rivera, G.M., Wagner, D.S., McCarty, J.H. (2015) Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Development (Cambridge, England). 142:4363-73
- Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J. (2012) betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8. Developmental Biology. 363(1):95-105
- Ablooglu, A.J., Kang, J., Handin, R.I., Traver, D., and Shattil, S.J. (2007) The zebrafish vitronectin receptor: Characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(8):2268-2276
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