Gene
irf3
- ID
- ZDB-GENE-071120-7
- Name
- interferon regulatory factor 3
- Symbol
- irf3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in head kidney. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihbjsk1 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-irf3 | Zhou et al., 2018 | |
| CRISPR2-irf3 | Zhou et al., 2018 | |
| CRISPR3-irf3 | Zebrafish Nomenclature Committee | |
| CRISPR4-irf3 | Pessoa Rodrigues et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7} | 616532 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Interferon regulatory factor-3 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z9B8 | InterPro | 444 | |||||||
| UniProtKB:B7SEE0 | InterPro | 426 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-94F20 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001143904 (1) | 1281 nt | ||
| Genomic | GenBank:BX276093 (1) | 38123 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z9B8 (1) | 444 aa |
- Li, Z., Li, J., Li, Z., Song, Y., Wang, Y., Wang, C., Yuan, L., Xiao, W., Wang, J. (2024) Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3. PLoS pathogens. 20:e1012227e1012227
- Muscò, A., Martini, D., Digregorio, M., Broccoli, V., Andreazzoli, M. (2024) Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Genes. 15(4):
- Pessoa Rodrigues, C., Collins, J.M., Yang, S., Martinez, C., Kim, J.W., Lama, C., Nam, A.S., Alt, C., Lin, C., Zon, L.I. (2024) Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells. Science (New York, N.Y.). 385:eadn1629eadn1629
- Qu, Z.L., Gong, X.Y., An, L.L., Sun, H.Y., Guo, W.H., Luan, H.Y., Wu, M.Y., Dan, C., Gui, J.F., Zhang, Y.B. (2024) Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience. 27:109497109497
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Grabinski, S.E., Parsana, D., Perkins, B.D. (2023) Comparative analysis of transcriptional changes in zebrafish cep290 and bbs2 mutants by RNA-seq reveals upregulation of inflammatory and stress-related pathways. Frontiers in molecular neuroscience. 16:11488401148840
- Li, Y.L., Gong, X.Y., Qu, Z.L., Zhao, X., Dan, C., Sun, H.Y., An, L.L., Gui, J.F., Zhang, Y.B. (2023) Zebrafish HERC7c Acts as an Inhibitor of Fish IFN Response. International Journal of Molecular Sciences. 24(5):
- Sellaththurai, S., Jung, S., Kim, M.J., Nadarajapillai, K., Ganeshalingam, S., Jeong, J.B., Lee, J. (2023) CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection. Biomolecules. 13(2):
- Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
- Xiong, S.T., Ying, Y.R., Long, Z., Li, J.H., Zhang, Y.B., Xiao, T.Y., Zhao, X. (2023) Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. International journal of biological macromolecules. 240:124384
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