Gene

irf3

ID

ZDB-GENE-071120-7

Name

interferon regulatory factor 3

Symbol

irf3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Enables transcription cis-regulatory region binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in head kidney. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With irf3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 7}	616532

Associated With irf3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019817	Interferon regulatory factor, conserved site
Domain	IPR001346	Interferon regulatory factor, DNA-binding domain
Domain	IPR019471	Interferon regulatory factor-3
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily