Gene
traf1
- ID
- ZDB-GENE-071120-4
- Name
- TNF receptor-associated factor 1
- Symbol
- traf1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity and tumor necrosis factor receptor binding activity. Predicted to be involved in regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Predicted to be active in cytoplasm. Orthologous to human TRAF1 (TNF receptor associated factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa21216 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR001293 | Zinc finger, TRAF-type |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR002083 | MATH/TRAF domain |
| Domain | IPR032070 | TNF receptor-associated factor, BIRC3 binding domain |
| Domain | IPR037306 | TNF receptor-associated factor 1, MATH domain |
| Domain | IPR049342 | TRAF1-6, MATH domain |
| Family | IPR012227 | TNF receptor-associated factor TRAF, metazoa |
| Homologous_superfamily | IPR008974 | TRAF-like |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | MATH/TRAF domain | TNF receptor-associated factor 1, MATH domain | TNF receptor-associated factor, BIRC3 binding domain | TNF receptor-associated factor TRAF, metazoa | TRAF1-6, MATH domain | TRAF-like | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, TRAF-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B0UXK1 | InterPro | 551 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-51B7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128381 (1) | 2220 nt | ||
| Genomic | GenBank:CR376844 (2) | 203472 nt | ||
| Polypeptide | UniProtKB:B0UXK1 (1) | 551 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- He, B.L., Yuan, J.M., Yang, L.Y., Xie, J.F., Weng, S.P., Yu, X.Q., and He, J.G. (2012) The Viral TRAF Protein (ORF111L) from Infectious Spleen and Kidney Necrosis Virus Interacts with TRADD and Induces Caspase 8-mediated Apoptosis. PLoS One. 7(5):e37001
- Xu, Z.Y., Sun, B.J., Chang, M.X., and Nie, P. (2008) Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 121(1-2):44-57
- Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251
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