Gene
traf5
- ID
- ZDB-GENE-071120-3
- Name
- Tnf receptor-associated factor 5
- Symbol
- traf5 Nomenclature History
- Previous Names
-
- si:ch211-284e20.7
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable signaling adaptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of canonical NF-kappaB signal transduction. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Predicted to be active in cytoplasm and cytoplasmic side of plasma membrane. Orthologous to human TRAF5 (TNF receptor associated factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15889 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | MATH/TRAF domain | TNF receptor-associated factor TRAF, metazoa | TRAF1-6, MATH domain | TRAF-like | Zinc finger, C3HC4 RING-type | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site | Zinc finger, TRAF-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PEP5 | InterPro | 542 | |||||||||
| UniProtKB:A0AB32TDI6 | InterPro | 487 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284E20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021469653 (1) | 4353 nt | ||
| Genomic | GenBank:AL954145 (2) | 160871 nt | ||
| Polypeptide | UniProtKB:A0A8M9PEP5 (1) | 542 aa |
- He, B.L., Yuan, J.M., Yang, L.Y., Xie, J.F., Weng, S.P., Yu, X.Q., and He, J.G. (2012) The Viral TRAF Protein (ORF111L) from Infectious Spleen and Kidney Necrosis Virus Interacts with TRADD and Induces Caspase 8-mediated Apoptosis. PLoS One. 7(5):e37001
- Xu, Z.Y., Sun, B.J., Chang, M.X., and Nie, P. (2008) Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Veterinary Immunology and Immunopathology. 121(1-2):44-57
- Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251
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