Gene
nod1
- ID
- ZDB-GENE-071116-9
- Name
- nucleotide-binding oligomerization domain containing 1
- Symbol
- nod1 Nomenclature History
- Previous Names
-
- NLR-A1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable CARD domain binding activity and oligopeptide binding activity. Acts upstream of or within defense response to other organism; hatching behavior; and regulation of MAPK cascade. Predicted to be located in cytoplasm. Is expressed in brain; digestive system; gill; pleuroperitoneal region; and unfertilized egg. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb44 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb52 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| sa12613 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17969 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa28761 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39133 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nod1 | (8) | |
| MO1-nod1 | N/A | Oehlers et al., 2011 |
| MO2-nod1 | N/A | Wu et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001315 | CARD domain |
| Domain | IPR007111 | NACHT nucleoside triphosphatase |
| Domain | IPR041075 | NOD1/2, winged helix domain |
| Domain | IPR041267 | NACHT, LRR and PYD domains-containing protein, helical domain HD2 |
| Family | IPR052201 | Leucine-rich repeat-containing regulator of pluripotency |
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Domain Details Per Protein
| Protein | Additional Resources | Length | CARD domain | Death-like domain superfamily | Leucine-rich repeat | Leucine-rich repeat-containing regulator of pluripotency | Leucine-rich repeat domain superfamily | NACHT, LRR and PYD domains-containing protein, helical domain HD2 | NACHT nucleoside triphosphatase | NOD1/2, winged helix domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RMD1 | InterPro | 940 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-143P5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002665060 (1) | 3444 nt | ||
| Genomic | GenBank:CU929399 (1) | 42381 nt | ||
| Polypeptide | UniProtKB:A0A8M1RMD1 (1) | 940 aa |
- Comparative Orthology
- Alliance
- Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130
- Novichkova, E., Nayak, S., Boussiba, S., Gopas, J., Zilberg, D., Khozin-Goldberg, I. (2023) Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD. Molecular Nutrition & Food Research. 67(6):e2200253
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Wu, X., Xiong, F., Fang, H., Zhang, J., Chang, M. (2021) Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel, Switzerland). 10(7):
- Chang, M.X., Xiong, F., Wu, X.M., Hu, Y.W. (2020) The expanding and function of NLRC3 or NLRC3-like in teleost fish: recent advances and novel insights. Developmental and comparative immunology. 114:103859
- Fang, H., Wu, X.M., Hu, Y.W., Song, Y.J., Zhang, J., Chang, M.X. (2020) NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. Developmental and comparative immunology. 112:103769
- Mai, Y., Peng, S., Li, H., Gao, Y., Lai, Z. (2020) NOD-like receptor signaling pathway activation: A potential mechanism underlying negative effects of benzo(α)pyrene on zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 240:108935
- Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231
- Xin, G., Li, W.G., Yoganandham, S.T., Jia, P.P., Ma, Y.B., Pei, D.S. (2020) Gut bacteria Vibrio sp. and Aeromonas sp. trigger the expression levels of proinflammatory cytokine: First evidence from the germ-free zebrafish. Fish & shellfish immunology. 106:518-525
- Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143
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