Gene
epor
- ID
- ZDB-GENE-071116-1
- Name
- erythropoietin receptor
- Symbol
- epor Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cytokine receptor activity. Acts upstream of or within hemopoiesis and pronephros development. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including digestive system; hematopoietic cell; hematopoietic system; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-epor | She et al., 2017 | |
| MO1-epor | N/A | (3) |
| MO2-epor | N/A | Paffett-Lugassy et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial erythrocytosis 1 | Alliance | [Erythrocytosis, familial, 1] | 133100 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR015152 | Growth hormone/erythropoietin receptor, ligand binding |
| Family | IPR009167 | Erythropoietin receptor |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
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Domain Details Per Protein
| Protein | Length | Erythropoietin receptor | Fibronectin type III | Fibronectin type III superfamily | Growth hormone/erythropoietin receptor, ligand binding | Immunoglobulin-like fold |
|---|---|---|---|---|---|---|
|
UniProtKB:Q2VBQ8
|
509 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-194E13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194775 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194778 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001043334 (1) | 1530 nt | ||
| Genomic | GenBank:CU570896 (1) | 180321 nt | ||
| Polypeptide | UniProtKB:Q2VBQ8 (1) | 509 aa |
- Sobah, M.L., Liongue, C., Ward, A.C. (2024) Stat3 regulates developmental hematopoiesis and impacts myeloid cell function via canonical and non-canonical modalities. Journal of Innate Immunity. 16(1):262-282
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Wang, G., Zhang, G., Li, Z., Fawcett, C.H., Coble, M., Sosa, M.X., Tsai, T., Malesky, K., Thibodeaux, S.J., Zhu, P., Glass, D.J., Fishman, M.C. (2019) Abnormal Behavior of Zebrafish Mutant in Dopamine Transporter Is Rescued by Clozapine. iScience. 17:325-333
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
- Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- She, J., Yuan, Z., Wu, Y., Chen, J., Kroll, J. (2017) Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Molecular metabolism. 8:189-202
- Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
- Lim, K.H., Chang, Y.C., Chiang, Y.H., Lin, H.C., Chang, C.Y., Lin, C.S., Huang, L., Wang, W.T., Gon-Shen Chen, C., Chou, W.C., Kuo, Y.Y. (2016) Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish. Blood cancer journal. 6:e481
- Chen, Y.H., Chang, C.F., Lai, Y.Y., Sun, C.Y., Ding, Y.J., Tsai, J.N. (2015) von Hippel-Lindau gene plays a role during zebrafish pronephros development. In vitro cellular & developmental biology. Animal. 51(10):1023-32
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