htr3a

ID

ZDB-GENE-071012-5

Name

5-hydroxytryptamine (serotonin) receptor 3A

Symbol

htr3a Nomenclature History

Previous Names

si:dkeyp-14b8.5

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable serotonin-gated monoatomic cation channel activity. Predicted to be involved in calcium ion transport and monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in dorsal telencephalon. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With htr3a Human Ortholog

No data available

Associated With htr3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018000	Neurotransmitter-gated ion-channel, conserved site
Domain	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
Domain	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
Domain	IPR049944	5-hydroxytryptamine 3 receptor, transmembrane domain
Family	IPR006201	Neurotransmitter-gated ion-channel
Family	IPR008132	5-hydroxytryptamine 3 receptor
Family	IPR008133	5-hydroxytryptamine 3 receptor, A subunit
Homologous_superfamily	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
Homologous_superfamily	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Homologous_superfamily	IPR038050	Neuronal acetylcholine receptor

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PD95	InterPro	388
UniProtKB:A0A8M3AM85	InterPro	482
UniProtKB:A0AB32T9Q1	InterPro	413
UniProtKB:A0AB32TDX3	InterPro	432
UniProtKB:A0AC58IB39	InterPro	494