Gene
dvl1b
- ID
- ZDB-GENE-071004-1
- Name
- dishevelled segment polarity protein 1b
- Symbol
- dvl1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Is predicted to enable frizzled binding activity. Involved in canonical Wnt signaling pathway and planar cell polarity pathway involved in neural tube closure. Acts upstream of or within Wnt signaling pathway; intracellular signal transduction; and multicellular organism development. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to human DVL1 (dishevelled segment polarity protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Costa et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant Robinow syndrome 2 | Alliance | Robinow syndrome, autosomal dominant 2 | 616331 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000591 | DEP domain |
Domain | IPR001158 | DIX domain |
Domain | IPR001478 | PDZ domain |
Domain | IPR003351 | Dishevelled protein domain |
Domain | IPR024580 | Dishevelled C-terminal |
Family | IPR008339 | Dishevelled family |
Family | IPR015506 | Dishevelled-related protein |
Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Homologous_superfamily | IPR036034 | PDZ superfamily |
Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Homologous_superfamily | IPR038207 | DIX domain superfamily |
Domain Details Per Protein
Protein | Length | DEP domain | Dishevelled C-terminal | Dishevelled family | Dishevelled protein domain | Dishevelled-related protein | DIX domain | DIX domain superfamily | PDZ domain | PDZ superfamily | Ubiquitin-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BGK1
|
742 | ||||||||||||
UniProtKB:A0A2R8QN77
|
707 | ||||||||||||
UniProtKB:A0A8M2BGP3
|
642 | ||||||||||||
UniProtKB:F1QNA4
|
716 | ||||||||||||
UniProtKB:A0A8M2BGL3
|
580 |
Interactions and Pathways
No data available
Plasmids
No data available