Gene

dvl1b

ID

ZDB-GENE-071004-1

Name

dishevelled segment polarity protein 1b

Symbol

dvl1b Nomenclature History

Previous Names

dvl1 (1)
dvl2l (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Is predicted to enable frizzled binding activity. Involved in canonical Wnt signaling pathway and planar cell polarity pathway involved in neural tube closure. Acts upstream of or within Wnt signaling pathway; intracellular signal transduction; and multicellular organism development. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to human DVL1 (dishevelled segment polarity protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Costa et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dvl1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant Robinow syndrome 2	Alliance	Robinow syndrome, autosomal dominant 2	616331

Associated With dvl1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000591	DEP domain
Domain	IPR001158	DIX domain
Domain	IPR001478	PDZ domain
Domain	IPR003351	Dishevelled protein domain
Domain	IPR024580	Dishevelled C-terminal
Family	IPR008339	Dishevelled family
Family	IPR015506	Dishevelled-related protein
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily
Homologous_superfamily	IPR038207	DIX domain superfamily

Domain Details Per Protein

Protein	Length	DEP domain	Dishevelled C-terminal	Dishevelled family	Dishevelled protein domain	Dishevelled-related protein	DIX domain	DIX domain superfamily	PDZ domain	PDZ superfamily	Ubiquitin-like domain superfamily	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M2BGK1 InterPro	742
UniProtKB:A0A2R8QN77 InterPro	707
UniProtKB:A0A8M2BGP3 InterPro	642
UniProtKB:F1QNA4 InterPro	716
UniProtKB:A0A8M2BGL3 InterPro	580