Gene
dvl1b
- ID
- ZDB-GENE-071004-1
- Name
- dishevelled segment polarity protein 1b
- Symbol
- dvl1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable frizzled binding activity. Predicted to be involved in canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway and intracellular signal transduction. Predicted to be active in cytosol. Is expressed in vertebral column. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to several human genes including DVL1 (dishevelled segment polarity protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Costa et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant Robinow syndrome 2 | Alliance | Robinow syndrome, autosomal dominant 2 | 616331 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000591 | DEP domain |
| Domain | IPR001158 | DIX domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR003351 | Dishevelled protein domain |
| Domain | IPR024580 | Dishevelled C-terminal |
| Family | IPR008339 | Dishevelled family |
| Family | IPR015506 | Dishevelled-related protein |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
| Homologous_superfamily | IPR038207 | DIX domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DEP domain | Dishevelled C-terminal | Dishevelled family | Dishevelled protein domain | Dishevelled-related protein | DIX domain | DIX domain superfamily | PDZ domain | PDZ superfamily | Ubiquitin-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BGK1 | InterPro | 742 | ||||||||||||
| UniProtKB:A0A2R8QN77 | InterPro | 707 | ||||||||||||
| UniProtKB:A0A8M2BGP3 | InterPro | 642 | ||||||||||||
| UniProtKB:F1QNA4 | InterPro | 716 | ||||||||||||
| UniProtKB:A0A8M2BGL3 | InterPro | 580 |
Interactions and Pathways
No data available
Plasmids
No data available