Gene
dync2i2
- ID
- ZDB-GENE-070928-9
- Name
- dynein 2 intermediate chain 2
- Symbol
- dync2i2 Nomenclature History
- Previous Names
-
- dync2i1
- wdr34
- zgc:171284 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to contribute to plus-end-directed microtubule motor activity. Acts upstream of or within intraciliary transport and neural tube development. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in ciliary plasm. Is expressed in central nervous system; pronephric duct; and retina. Used to study neural tube defect. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 11 with or without polydactyly. Orthologous to human DYNC2I2 (dynein 2 intermediate chain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Krock et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| short-rib thoracic dysplasia 11 with or without polydactyly | Alliance | Short-rib thoracic dysplasia 11 with or without polydactyly | 615633 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| neural tube defect | AB + MO1-dync2i2 | standard conditions | Yin et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dynein Intermediate Chain | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A7MD87
|
501 |
Interactions and Pathways
No data available
Plasmids
No data available