Gene

egf

ID
ZDB-GENE-070922-1
Name
epidermal growth factor
Symbol
egf Nomenclature History
Previous Names
  • sb:eu639
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and growth factor activity. Involved in blood circulation and cartilage development. Predicted to localize to plasma membrane. Is expressed in several structures, including central nervous system; notochord; opercular flap; pleuroperitoneal region; and scale. Human ortholog(s) of this gene implicated in several diseases, including Zollinger-Ellison syndrome; hepatobiliary system cancer (multiple); high grade glioma (multiple); lung non-small cell carcinoma (multiple); and primary hypomagnesemia (multiple). Orthologous to human EGF (epidermal growth factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Pruvot et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egf Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal hypomagnesemia 4 Alliance Hypomagnesemia 4, renal 611718
Associated With egf Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR016317 Pro-epidermal growth factor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR000033 LDLR class B repeat
Domain Details Per Protein
Protein Length EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily LDLR class B repeat Pro-epidermal growth factor Six-bladed beta-propeller, TolB-like
UniProtKB:A0A140LGI0 1176
UniProtKB:B3DH82 1113
UniProtKB:F1QKU8 1114
UniProtKB:Q6VQA2 1114
UniProtKB:F1QGQ2 1113
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations