Gene
serpine1
- ID
- ZDB-GENE-070912-60
- Name
- serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- Symbol
- serpine1 Nomenclature History
- Previous Names
-
- PAI-1 (1)
- si:ch211-138a11.1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits serine-type endopeptidase inhibitor activity. Involved in negative regulation of plasminogen activation. Predicted to localize to extracellular space. Is expressed in heart. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1).
- Genome Resources
- Note
- None
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Plasminogen activator inhibitor-1 deficiency | 613329 | ||
{Transcription of plasminogen activator inhibitor, modulator of} |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR023795 | Serpin, conserved site |
Domain | IPR023796 | Serpin domain |
Family | IPR000215 | Serpin family |
Homologous_superfamily | IPR036186 | Serpin superfamily |
Homologous_superfamily | IPR042178 | Serpin superfamily, domain 1 |
Homologous_superfamily | IPR042185 | Serpin superfamily, domain 2 |
Domain Details Per Protein
Protein | Length | Serpin, conserved site | Serpin domain | Serpin family | Serpin superfamily | Serpin superfamily, domain 1 | Serpin superfamily, domain 2 |
---|---|---|---|---|---|---|---|
UniProtKB:A8WGQ0
|
384 | ||||||
UniProtKB:F1QRB8
|
392 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
serpine1-201
(1)
|
1789 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl