Gene
dcaf8
- ID
- ZDB-GENE-070912-578
- Name
- DDB1 and CUL4 associated factor 8
- Symbol
- dcaf8 Nomenclature History
- Previous Names
-
- si:dkey-75g22.6 (1)
- si:rp71-1g18.15
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in giant axonal neuropathy 2. Orthologous to several human genes including DCAF8 (DDB1 and CUL4 associated factor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| giant axonal neuropathy 2 | Alliance | ?Giant axonal neuropathy 2, autosomal dominant | 610100 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DDB1- and CUL4-associated factor 8-like | WD40 repeat | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:F1QF18
|
607 |
Interactions and Pathways
No data available
Plasmids
No data available