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ZIRC
ZFIN ID: ZDB-GENE-070912-525
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Gene Name: pappalysin 2
Gene Symbol: pappa2    Nomenclature History

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Previous Name: si:dkey-39f8.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits peptidase activity. Involved in several processes, including angiogenesis; notochord development; and regulation of Notch signaling pathway. Is expressed in several structures, including axial mesoderm; bone tissue; nervous system; pleuroperitoneal region; and ventral mandibular arch. Orthologous to human PAPPA2 (pappalysin 2).
Genome Resources: Alliance (1),  Gene:567038 (1), 
GENE EXPRESSION
All Expression Data: Fig. 2 from Kjaer-Sorensen et al., 2014
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17244 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa25852 Point Mutation Unknown Splice Site ENU
    sa32959 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa32960 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa32961 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa39870 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44537 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pappa2 N/A 1
    MO2-pappa2 N/A 1
    MO3-pappa2 N/A 1
    PHENOTYPE
    Data: 4 figures from Kjaer-Sorensen et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH pappa2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pappa2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Molecular Function peptidase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000436 (1)
  • InterPro:IPR000800 (1)
  • InterPro:IPR006558 (1)
  • InterPro:IPR008754 (1)
  • InterPro:IPR011936 (1)
  • InterPro:IPR013320 (1)
  • InterPro:IPR026918 (1)
  • InterPro:IPR035976 (1)
  • PROSITE:PS50923 (1)
  • Pfam:PF00084 (1)
  • Pfam:PF05572 (1)
  • Pfam:PF13948 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pappa2-201 (1)    Ensembl 6727
    Select Tool
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pappa2 No data available
    MARKER RELATIONSHIPS
    pappa2 Contained in: [BAC] CH211-153C18 (1) (order this), DKEY-21A8 (1) (order this), DKEY-39F8 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_690325 (1) 6684 bp
    Select Tool
    Genomic GenBank:CR388403 (1) 159100 bp
    Select Tool
    Polypeptide UniProtKB:E9QCK7 (1) 1731 aa
    Select Tool
    Sequence Information (all 11)
    ORTHOLOGY for pappa2 ( Chr: 2 )
    CITATIONS (14)