Gene
pappa2
- ID
- ZDB-GENE-070912-525
- Name
- pappalysin 2
- Symbol
- pappa2 Nomenclature History
- Previous Names
-
- si:dkey-39f8.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables peptidase activity. Acts upstream of or within several processes, including angiogenesis; notochord development; and regulation of Notch signaling pathway. Predicted to be active in extracellular space. Is expressed in several structures, including axial mesoderm; bone tissue; nervous system; pleuroperitoneal region; and ventral mandibular arch. Orthologous to human PAPPA2 (pappalysin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kjaer-Sorensen et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Kjaer-Sorensen et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Short stature, Dauber-Argente type | 619489 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000436 | Sushi/SCR/CCP domain |
| Domain | IPR000800 | Notch domain |
| Domain | IPR006558 | LamG-like jellyroll fold |
| Domain | IPR008754 | Peptidase M43, pregnancy-associated plasma-A |
| Family | IPR043543 | Pappalysin-1/2 |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR035976 | Sushi/SCR/CCP superfamily |
| Repeat | IPR011936 | Myxococcus cysteine-rich repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | LamG-like jellyroll fold | Metallopeptidase, catalytic domain superfamily | Myxococcus cysteine-rich repeat | Notch domain | Pappalysin-1/2 | Peptidase M43, pregnancy-associated plasma-A | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E9QCK7 | InterPro | 1731 | |||||||||
| UniProtKB:A0A8M3B0D2 | InterPro | 1730 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pappa2-201
(1)
|
Ensembl | 6,727 nt |
Interactions and Pathways
No data available
Plasmids
No data available