Gene

htr2aa

ID
ZDB-GENE-070912-500
Name
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
Symbol
htr2aa Nomenclature History
Previous Names
  • htr2a
  • si:dkey-284e7.1
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have G protein-coupled serotonin receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and release of sequestered calcium ion into cytosol. Predicted to localize to dendrite and integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htr2aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
melancholic depression Alliance {Major depressive disorder, response to citalopram therapy in} 608516
schizophrenia Alliance {Schizophrenia, susceptibility to} 181500
{Obsessive-compulsive disorder, susceptibility to} 164230
Associated With htr2aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR002231 5-hydroxytryptamine receptor family
Domain Details Per Protein
Protein Length 5-hydroxytryptamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:A0A8N7TD42 491
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA htr2aa-201 (1) Ensembl 1,208 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations