Gene
dars2
- ID
- ZDB-GENE-070912-443
- Name
- aspartyl-tRNA synthetase 2, mitochondrial
- Symbol
- dars2 Nomenclature History
- Previous Names
-
- si:dkey-21n10.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; aminoacyl-tRNA ligase activity; and nucleic acid binding activity. Predicted to be involved in tRNA aminoacylation for protein translation. Predicted to localize to cytoplasm. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation | 611105 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004364 | Aminoacyl-tRNA synthetase, class II (D/K/N) |
| Domain | IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR029351 | GAD domain |
| Domain | IPR047089 | Aspartate-tRNA ligase, type 1, anticodon recognition domain |
| Domain | IPR047090 | Aspartate-tRNA ligase, type 1, core domain |
| Family | IPR002312 | Aspartyl/Asparaginyl-tRNA synthetase, class IIb |
| Family | IPR004524 | Aspartate-tRNA ligase, type 1 |
| Homologous_superfamily | IPR004115 | GAD-like domain superfamily |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (D/K/N) | Aspartate-tRNA ligase, type 1 | Aspartate-tRNA ligase, type 1, anticodon recognition domain | Aspartate-tRNA ligase, type 1, core domain | Aspartyl/Asparaginyl-tRNA synthetase, class IIb | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | GAD domain | GAD-like domain superfamily | Nucleic acid-binding, OB-fold | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QFP3
|
660 |
Interactions and Pathways
No data available
Plasmids
No data available