Gene
dars2
- ID
- ZDB-GENE-070912-443
- Name
- aspartyl-tRNA synthetase 2, mitochondrial
- Symbol
- dars2 Nomenclature History
- Previous Names
-
- si:dkey-21n10.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation | 611105 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004364 | Aminoacyl-tRNA synthetase, class II (D/K/N) |
| Domain | IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR029351 | GAD domain |
| Domain | IPR047089 | Aspartate-tRNA ligase, type 1, anticodon recognition domain |
| Domain | IPR047090 | Aspartate-tRNA ligase, type 1, core domain |
| Family | IPR002312 | Aspartyl/Asparaginyl-tRNA synthetase, class IIb |
| Family | IPR004524 | Aspartate-tRNA ligase, type 1 |
| Homologous_superfamily | IPR004115 | GAD-like domain superfamily |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (D/K/N) | Aspartate-tRNA ligase, type 1 | Aspartate-tRNA ligase, type 1, anticodon recognition domain | Aspartate-tRNA ligase, type 1, core domain | Aspartyl/Asparaginyl-tRNA synthetase, class IIb | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | GAD domain | GAD-like domain superfamily | Nucleic acid-binding, OB-fold | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QFP3
|
660 |
Interactions and Pathways
No data available
Plasmids
No data available