ZFIN is now using GRCz12tu for Genomic Data
Gene
prkag2b
- ID
- ZDB-GENE-070912-442
- Name
- protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
- Symbol
- prkag2b Nomenclature History
- Previous Names
-
- prkag2
- si:ch211-230l11.1
- si:dkey-217f4.2
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to act upstream of or within fatty acid biosynthetic process and phosphorylation. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Meireles et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypertrophic cardiomyopathy 6 | Alliance | Cardiomyopathy, hypertrophic 6 | 600858 |
| lethal congenital glycogen storage disease of heart | Alliance | Glycogen storage disease of heart, lethal congenital | 261740 |
| Wolff-Parkinson-White syndrome | Alliance | Wolff-Parkinson-White syndrome | 194200 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AMP-activated protein kinase gamma/SDS23 families | CBS domain | CBS domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1QRT4 | InterPro | 533 | |||
| UniProtKB:A0A8M2BAB8 | InterPro | 532 | |||
| UniProtKB:A0AB32TA76 | InterPro | 453 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkag2b-201
(1)
|
Ensembl | 2,139 nt | ||
| mRNA |
prkag2b-202
(1)
|
Ensembl | 1,473 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers