Gene

prkag2b

ID
ZDB-GENE-070912-442
Name
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
Symbol
prkag2b Nomenclature History
Previous Names
  • prkag2
  • si:ch211-230l11.1
  • si:dkey-217f4.2
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; protein phosphorylation; and regulation of catalytic activity. Predicted to act upstream of or within regulation of protein serine/threonine kinase activity. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Meireles et al., 2018
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkag2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypertrophic cardiomyopathy 6 Alliance Cardiomyopathy, hypertrophic 6 600858
lethal congenital glycogen storage disease of heart Alliance Glycogen storage disease of heart, lethal congenital 261740
Wolff-Parkinson-White syndrome Alliance Wolff-Parkinson-White syndrome 194200
Associated With prkag2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000644 CBS domain
Family IPR039170 5'-AMP-activated protein kinase subunit gamma-2
Domain Details Per Protein
Protein Length 5'-AMP-activated protein kinase subunit gamma-2 CBS domain
UniProtKB:F1QRT4 533
UniProtKB:A0A2R8QBR6 490
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations