Gene

prkag2b

ID

ZDB-GENE-070912-442

Name

protein kinase, AMP-activated, gamma 2 non-catalytic subunit b

Symbol

prkag2b Nomenclature History

Previous Names

prkag2
si:ch211-230l11.1
si:dkey-217f4.2

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have adenyl ribonucleotide binding activity. Predicted to be involved in regulation of protein serine/threonine kinase activity. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to human PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Meireles et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkag2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypertrophic cardiomyopathy 6	Alliance	Cardiomyopathy, hypertrophic 6	600858
lethal congenital glycogen storage disease of heart	Alliance	Glycogen storage disease of heart, lethal congenital	261740
Wolff-Parkinson-White syndrome	Alliance	Wolff-Parkinson-White syndrome	194200

Associated With prkag2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000644	CBS domain
Family	IPR050511	AMP-activated protein kinase gamma/SDS23 families
Homologous_superfamily	IPR046342	CBS domain superfamily

Domain Details Per Protein

Protein	Length	AMP-activated protein kinase gamma/SDS23 families	CBS domain	CBS domain superfamily
UniProtKB:F1QRT4 InterPro	533
UniProtKB:A0A8M2BAB8 InterPro	532

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	prkag2b-201 (1) Ensembl	Ensembl		2,139 nt	Select Tool
mRNA	prkag2b-202 (1) Ensembl	Ensembl		1,473 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations