Gene

si:dkey-18p12.4

ID

ZDB-GENE-070912-408

Name

si:dkey-18p12.4

Symbol

si:dkey-18p12.4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including MEFV (MEFV innate immunity regulator, pyrin); TRIM14 (tripartite motif containing 14); and TRIM31 (tripartite motif containing 31).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With si:dkey-18p12.4 Human Ortholog

No data available

Associated With si:dkey-18p12.4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001870	B30.2/SPRY domain
Domain	IPR003877	SPRY domain
Domain	IPR003879	Butyrophylin-like, SPRY domain
Domain	IPR006574	SPRY-associated
Family	IPR050143	Tripartite motif-containing
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR043136	B30.2/SPRY domain superfamily