Gene

nlrc9

ID

ZDB-GENE-070912-362

Name

NLR family CARD domain containing 9

Symbol

nlrc9 Nomenclature History

Previous Names

NACHT, LRR and PYD domains-containing protein 3 isoform X1 (1)
si:dkey-121n8.3

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Human ortholog(s) of this gene implicated in Muckle-Wells syndrome; autoimmune disease (multiple); autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome (multiple); and urticaria. Orthologous to several human genes including NLRP1 (NLR family pyrin domain containing 1); NLRP12 (NLR family pyrin domain containing 12); and NLRP13 (NLR family pyrin domain containing 13).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nlrc9 Human Ortholog

No data available

Associated With nlrc9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007111	NACHT nucleoside triphosphatase
Domain	IPR029495	NACHT-associated domain
Domain	IPR041075	NOD1/2, winged helix domain
Domain	IPR041267	NACHT, LRR and PYD domains-containing protein, helical domain HD2
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR006553	Leucine-rich repeat, cysteine-containing subtype

Domain Details Per Protein

Protein	Length	Leucine-rich repeat	Leucine-rich repeat, cysteine-containing subtype	Leucine-rich repeat domain superfamily	NACHT-associated domain	NACHT, LRR and PYD domains-containing protein, helical domain HD2	NACHT nucleoside triphosphatase	NOD1/2, winged helix domain	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M2B434 InterPro	1056

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nlrc9-201 (1) Ensembl	Ensembl	2,435 nt	Select Tool ZFIN BLAST
mRNA	nlrc9-202 (1) Ensembl	Ensembl	3,130 nt	Select Tool ZFIN BLAST
mRNA	nlrc9-203 (1) Ensembl	Ensembl	2,441 nt	Select Tool ZFIN BLAST
mRNA	nlrc9-204 (1) Ensembl	Ensembl	243 nt	Select Tool ZFIN BLAST
mRNA	nlrc9-205 (1) Ensembl	Ensembl	2,553 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations