Gene
slitrk3b
- ID
- ZDB-GENE-070912-352
- Name
- SLIT and NTRK-like family, member 3b
- Symbol
- slitrk3b Nomenclature History
- Previous Names
-
- si:dkey-116g14.1
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to be involved in axonogenesis and positive regulation of synapse assembly. Predicted to act upstream of or within regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be active in GABA-ergic synapse and postsynaptic density membrane. Is expressed in head; nervous system; and neuroepithelial cell. Orthologous to human SLITRK3 (SLIT and NTRK like family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Round et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slitrk3b | (2) | |
| CRISPR2-slitrk3b | (2) | |
| CRISPR3-slitrk3b | (2) | |
| CRISPR4-slitrk3b | (2) | |
| CRISPR5-slitrk3b | (2) | |
| CRISPR6-slitrk3b | (2) | |
| CRISPR7-slitrk3b | (2) | |
| CRISPR8-slitrk3b | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cysteine-rich flanking region, C-terminal | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype |
|---|---|---|---|---|---|---|
| UniProtKB:B0S7B6 | InterPro | 882 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slitrk3b-201
(1)
|
Ensembl | 2,649 nt | ||
| mRNA |
slitrk3b-202
(1)
|
Ensembl | 3,043 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-116G14 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001346099 (1) | |||
| Genomic | GenBank:BX663495 (1) | 80339 nt | ||
| Polypeptide | UniProtKB:B0S7B6 (1) | 882 aa |
- Moreno-Mateos, M.A., Vejnar, C.E., Beaudoin, J.D., Fernandez, J.P., Mis, E.K., Khokha, M.K., Giraldez, A.J. (2015) CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo. Nature Methods. 12:982-8
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
- Round, J., Ross, B., Angel, M., Shields, K., and Lom, B. (2014) Slitrk gene duplication and expression in the developing zebrafish nervous system. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(2):339-49
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