ZFIN ID: ZDB-GENE-070912-330
Gene Name: interferon regulatory factor 4a
Gene Symbol: irf4a    Nomenclature History

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Previous Names: irf4, si:ch73-170d1.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in lymphoid lineage cell migration into thymus; lymphoid progenitor cell differentiation; and negative regulation of myeloid cell differentiation. Localizes to chromatin and nucleus. Is expressed in several structures, including hematopoietic multipotent progenitor cell; hematopoietic system; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; anaplastic large cell lymphoma; chronic lymphocytic leukemia; multiple myeloma; and peripheral T-cell lymphoma. Orthologous to human IRF4 (interferon regulatory factor 4).
Genome Resources: Alliance (1),  Gene:100002070 (1),  Ensembl(GRCz11):ENSDARG00000006560 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ioz2Tg Transgenic Insertion Exon 1 Unknown DNA_AND_TALEN
ioz3 Small Deletion Exon 1 Unknown TALEN
sa12189 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-irf4a N/A 1
    MO2-irf4a N/A 1
    TALEN1-irf4a 1
    TALEN2-irf4a
    1
    DISEASE ASSOCIATED WITH irf4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    [Skin/hair/eye pigmentation, variation in, 8] 611724
    DISEASE ASSOCIATED WITH irf4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymphoid lineage cell migration into thymus (more)
    Cellular Component chromatin (more)
    Molecular Function DNA-binding transcription activator activity, RNA polymerase II-specific (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irf4a-201 (1)    Ensembl 1633
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irf4a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.9irf4a:GFP) irf4a GFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    irf4a Contained in: [BAC] CH73-170D1 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001122710 (1) 1633 nt
    Genomic GenBank:CT962510 (1) 85653 nt
    Select Tool
    Polypeptide UniProtKB:A8B8L1 (1) 460 aa
    Sequence Information (all 8)
    ORTHOLOGY for irf4a ( Chr: 2 )
    CITATIONS (35)