Gene
rit1
- ID
- ZDB-GENE-070912-329
- Name
- Ras-like without CAAX 1
- Symbol
- rit1 Nomenclature History
- Previous Names
-
- si:ch211-93a2.3
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have GTPase activity; calmodulin binding activity; and purine ribonucleoside binding activity. Involved in embryonic viscerocranium morphogenesis and heart development. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 8. Orthologous to several human genes including RIT1 (Ras like without CAAX 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 8 | Alliance | Noonan syndrome 8 | 615355 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase, Ras-type | Small GTP-binding protein domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P1Y7
|
181 | ||||
|
UniProtKB:B3DJU3
|
211 |
Interactions and Pathways
No data available
Plasmids
No data available