Gene
hbl4
- ID
- ZDB-GENE-070912-287
- Name
- hexose-binding lectin 4
- Symbol
- hbl4 Nomenclature History
- Previous Names
-
- si:ch211-284o19.5
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable carbohydrate binding activity. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. Predicted to be active in extracellular space and multivesicular body. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018378 | C-type lectin, conserved site |
| Domain | IPR001304 | C-type lectin-like |
| Domain | IPR033990 | Collectin, C-type lectin-like domain |
| Family | IPR051077 | Calcium-dependent Lectin |
| Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium-dependent Lectin | Collagen triple helix repeat | Collectin, C-type lectin-like domain | C-type lectin, conserved site | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A9JSU1 | InterPro | 245 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-284O19 | ||
| Encodes | cDNA | MGC:171520 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114725 (1) | 1145 nt | ||
| Genomic | GenBank:AL954692 (1) | 101677 nt | ||
| Polypeptide | UniProtKB:A9JSU1 (1) | 245 aa |
No data available
- Fehrmann-Cartes, K., Coronado, M., Hernández, A.J., Allende, M.L., Feijoo, C.G. (2019) Anti-inflammatory effects of aloe vera on soy meal-induced intestinal inflammation in zebrafish. Fish & shellfish immunology. 95:564-573
- Wang, Z., Li, G., Wu, Q., Liu, C., Shen, J., Yan, W. (2018) Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish. Chemosphere. 214:598-605
- Blaser, B.W., Moore, J.L., Hagedorn, E.J., Li, B., Riquelme, R., Lichtig, A., Yang, S., Zhou, Y., Tamplin, O.J., Binder, V., Zon, L.I. (2017) CXCR1 remodels the vascular niche to promote hematopoietic stem and progenitor cell engraftment. The Journal of experimental medicine. 214(4):1011
- Zhang, H., Peatman, E., Liu, H., Niu, D., Feng, T., Kucuktas, H., Waldbieser, G., Chen, L., and Liu, Z. (2012) Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus). Research in Veterinary Science. 92(3):408-413
- Jackson, A.N., McLure, C.A., Dawkins, R.L., and Keating, P.J. (2007) Mannose binding lectin (MBL) copy number polymorphism in Zebrafish (D. rerio) and identification of haplotypes resistant to L. anguillarum. Immunogenetics. 59(11):861-872
- Nakao, M., Kajiya, T., Sato, Y., Somamoto, T., Kato-Unoki, Y., Matsushita, M., Nakata, M., Fujita, T., and Yano, T. (2006) Lectin Pathway of Bony Fish Complement: Identification of Two Homologs of the Mannose-Binding Lectin Associated with MASP2 in the Common Carp (Cyprinus carpio). Journal of immunology (Baltimore, Md. : 1950). 177(8):5471-5479
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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