Gene

adap2

ID
ZDB-GENE-070912-21
Name
ArfGAP with dual PH domains 2
Symbol
adap2 Nomenclature History
Previous Names
  • si:ch211-11k18.11 (1)
  • si:ch73-33i10.5
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within atrioventricular valve development; heart jogging; and heart looping. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and plasma membrane. Is expressed in several structures, including digestive system; gonad; head; heart; and skeletal muscle. Orthologous to human ADAP2 (ArfGAP with dual PH domains 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Venturin et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa6893Allele with one point mutationUnknownSplice SiteENU
sa9788Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
sa40066Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-adap2N/AVenturin et al., 2014
MO2-adap2N/AVenturin et al., 2014
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Human Disease
Associated With adap2 Human Ortholog
No data available
Associated With adap2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001164 Arf GTPase activating protein
Domain IPR001849 Pleckstrin homology domain
Domain IPR037849 ADAP, PH domain 1
Domain IPR037851 ADAP, PH domain 2
Family IPR052589 Arf-GAP with dual PH domain-containing protein
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Length ADAP, PH domain 1 ADAP, PH domain 2 ArfGAP domain superfamily ARFGAP/RecO-like zinc finger Arf-GAP with dual PH domain-containing protein Arf GTPase activating protein PH-like domain superfamily Pleckstrin homology domain
UniProtKB:A0A8M9Q881
InterPro
418
UniProtKB:E9QE78
InterPro
378
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adap2-201 (1)
Ensembl
Ensembl 1,291 nt
ZFIN BLAST
ncRNA adap2-002 (1)
Ensembl
Ensembl 837 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-33I10ZFIN Curated Data
Contained inBACCH211-11K18ZFIN Curated Data
Contained inFosmidCH1073-455J6ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:XM_021473800 (1)1848 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:BX511232171843 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A8M9Q881 (1)418 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanADAP217
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseAdap211
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
TSV
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