Gene
dhx9
- ID
- ZDB-GENE-070912-171
- Name
- DEAH (Asp-Glu-Ala-His) box helicase 9
- Symbol
- dhx9 Nomenclature History
- Previous Names
-
- si:ch211-194i4.1
- wu:fe02c10
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity; RNA binding activity; and helicase activity. Acts upstream of or within response to virus. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 75. Orthologous to human DHX9 (DExH-box helicase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa8582 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13148 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18641 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19813 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32962 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39873 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39874 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa39875 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45108 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 75 | Alliance | Intellectual developmental disorder, autosomal dominant 75 | 620988 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR007502 | Helicase-associated domain |
| Domain | IPR011545 | DEAD/DEAH box helicase domain |
| Domain | IPR011709 | DEAD-box helicase, OB fold |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DEAD-box helicase, OB fold | DEAD/DEAH box helicase domain | DHX9, DEXH-box helicase domain | DHX9, first double-stranded RNA binding domain | DHX9, second double-stranded RNA binding domain | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Double-stranded RNA-binding domain | Helicase-associated domain | Helicase associated domain (HA2), winged-helix domain | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8F5CC50 | InterPro | |||||||||||||
| UniProtKB:A0A8M3AQB4 | InterPro | 1062 | ||||||||||||
| UniProtKB:A0A8M1P3F9 | InterPro | 1270 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194I4 | ZFIN Curated Data | |
| Encodes | EST | fe02c10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001201444 (1) | 4135 nt | ||
| Genomic | GenBank:BX571812 (2) | 69979 nt | ||
| Polypeptide | UniProtKB:A0A8M1P3F9 (1) | 1270 aa |
- Zhao, N., Wang, X., Wang, T., Xu, X., Liu, Q., Li, J. (2022) Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). International Journal of Molecular Sciences. 23(18)
- Mojzesz, M., Klak, K., Wojtal, P., Adamek, M., Podlasz, P., Chmielewska-Krzesinska, M., Matras, M., Reichert, M., Chadzinska, M., Rakus, K. (2020) Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp. Fish & shellfish immunology. 104:62-73
- Widziolek, M., Janik, K., Mojzesz, M., Pooranachandran, N., Adamek, M., Pecio, A., Surachetpong, W., Levraud, J.P., Boudinot, P., Chadzinska, M., Rakus, K. (2020) Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection. Developmental and comparative immunology. 116:103936
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ge, R., Zhou, Y., Peng, R., Wang, R., Li, M., Zhang, Y., Zheng, C., Wang, C. (2015) Conservation of the STING-mediated cytosolic DNA sensing pathway in zebrafish. Journal of virology. 89(15):7696-706
- Sztal, T., Berger, S., Currie, P.D., and Hall, T.E. (2011) Characterization of the laminin gene family and evolution in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(2):422-431
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