Gene
asap1a
- ID
- ZDB-GENE-070912-129
- Name
- ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a
- Symbol
- asap1a Nomenclature History
- Previous Names
-
- si:ch211-160i2.3
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within defense response to bacterium and positive regulation of macrophage migration. Predicted to be located in cytoplasm. Is expressed in head. Orthologous to human ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Cui et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AH/BAR domain superfamily | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | ArfGAP domain superfamily | ARFGAP/RecO-like zinc finger | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein | Arf GTPase activating protein | ASAP1, BAR domain | ASAP1, SH3 domain | ASAP, PH domain | BAR domain | PH-like domain superfamily | Pleckstrin homology domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BAL2
|
1100 | |||||||||||||||
|
UniProtKB:A0A0R4IM47
|
1097 | |||||||||||||||
|
UniProtKB:A0A8M2BAX6
|
1151 | |||||||||||||||
|
UniProtKB:B3DI91
|
1077 | |||||||||||||||
|
UniProtKB:A0A8M2BAL0
|
1154 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
asap1a-201
(1)
|
Ensembl | 3,421 nt | ||
| mRNA |
asap1a-202
(1)
|
Ensembl | 3,615 nt | ||
| mRNA |
asap1a-203
(1)
|
Ensembl | 8,880 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160I2 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194524 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001130663 (1) | 3421 nt | ||
| Genomic | GenBank:BX663499 (1) | 195369 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAL0 (1) | 1154 aa |
- Dalla Barba, F., Soardi, M., Mouhib, L., Risato, G., Akyürek, E.E., Lucon-Xiccato, T., Scano, M., Benetollo, A., Sacchetto, R., Richard, I., Argenton, F., Bertolucci, C., Carotti, M., Sandonà, D. (2023) Modeling Sarcoglycanopathy in Danio rerio. International Journal of Molecular Sciences. 24(16):
- Cui, J., Chen, G., Wen, D., Wang, Y., Zhao, Z., Wu, C. (2020) Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration. Frontiers in cellular and infection microbiology. 10:519503
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ningappa, M., So, J., Glessner, J., Ashokkumar, C., Ranganathan, S., Min, J., Higgs, B.W., Sun, Q., Haberman, K., Schmitt, L., Vilarinho, S., Mistry, P.K., Vockley, G., Dhawan, A., Gittes, G.K., Hakonarson, H., Jaffe, R., Subramaniam, S., Shin, D., Sindhi, R. (2015) The Role of ARF6 in Biliary Atresia. PLoS One. 10:e0138381
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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