Gene

cd28

ID

ZDB-GENE-070912-128

Name

CD28 molecule

Symbol

cd28 Nomenclature History

Previous Names

ctla4 (1)
si:ch211-160b7.1

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to be involved in regulation of T cell proliferation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cd28 Human Ortholog

No data available

Associated With cd28 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013106	Immunoglobulin V-set domain
Family	IPR040216	Cytotoxic T-lymphocyte protein 4/CD28
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Cytotoxic T-lymphocyte protein 4/CD28	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin V-set domain
UniProtKB:A0A8M2BEX8 InterPro	209

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cd28-202 (1) Ensembl	Havana	700 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations