Gene
trpc1
- ID
- ZDB-GENE-070830-1
- Name
- transient receptor potential cation channel, subfamily C, member 1
- Symbol
- trpc1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Acts upstream of or within angiogenesis; filopodium assembly; and vasculogenesis. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in bulbus arteriosus; head; integument; and nervous system. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Yu et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa37817 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-trpc1 | N/A | Yu et al., 2010 |
| MO2-trpc1 | N/A | Yu et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013555 | Transient receptor ion channel domain |
| Family | IPR002153 | Transient receptor potential channel, canonical |
| Family | IPR005457 | Transient receptor potential channel, canonical 1 |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
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Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical | Transient receptor potential channel, canonical 1 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E1U7G1
|
796 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157J23 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001198661 (1) | 2734 nt | ||
| Genomic | GenBank:BX470196 (2) | 52600 nt | ||
| Polypeptide | UniProtKB:E1U7G1 (1) | 796 aa |
- Gupta, R.K., Wasilewska, I., Palchevska, O., Kuźnicki, J. (2020) Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. International Journal of Molecular Sciences. 21(17):
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- von Niederhäusern, V., Kastenhuber, E., Stäuble, A., Gesemann, M., and Neuhauss, S.C. (2013) Phylogeny and expression of canonical transient receptor potential (TRPC) genes in developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(12):1427-41
- Yu, P.C., Gu, S.Y., Bu, J.W., and Du, J.L. (2010) TRPC1 Is Essential for In Vivo Angiogenesis in Zebrafish. Circulation research. 106(7):1221-1232
- Petko, J.A., Kabbani, N., Frey, C., Woll, M., Hickey, K., Craig, M., Canfield, V.A., and Levenson, R. (2009) Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neuroscience. 10:27
- Möller, C.C., Mangos, S., Drummond, I.A., and Reiser, J. (2008) Expression of trpC1 and trpC6 orthologs in zebrafish. Gene expression patterns : GEP. 8(5):291-296
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