Gene

chrnb2

ID
ZDB-GENE-070821-3
Name
cholinergic receptor, nicotinic, beta 2
Symbol
chrnb2 Nomenclature History
Previous Names
  • chrnb2
  • chrnb2b (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in membrane depolarization; monoatomic ion transmembrane transport; and synaptic signaling. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa17637Allele with one point mutationUnknownPremature StopENU
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-chrnb2
    Saraswathy et al., 2024
    1 - 1 of 1
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    Human Disease
    Associated With chrnb2 Human Ortholog
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nocturnal frontal lobe epilepsy 3 Alliance Epilepsy, nocturnal frontal lobe, 3 605375
    1 - 1 of 1
    Associated With chrnb2 Via Experimental Models
    No data available
    Gene Ontology
    Protein Domains
    Domain, Family, and Site Summary
    Type InterPro ID Name
    Conserved_site IPR018000 Neurotransmitter-gated ion-channel, conserved site
    Domain IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    Domain IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    Family IPR002394 Nicotinic acetylcholine receptor
    Family IPR006201 Neurotransmitter-gated ion-channel
    1 - 5 of 8 Show all
    Domain Details Per Protein
    Protein Additional Resources Length Neuronal acetylcholine receptor Neurotransmitter-gated ion-channel Neurotransmitter-gated ion-channel, conserved site Neurotransmitter-gated ion-channel ligand-binding domain Neurotransmitter-gated ion-channel ligand-binding domain superfamily Neurotransmitter-gated ion-channel transmembrane domain Neurotransmitter-gated ion-channel transmembrane domain superfamily Nicotinic acetylcholine receptor
    UniProtKB:E7F4S7 InterPro 543
    1 - 1 of 1
    Transcripts
    Genome Browsers
    Genome Build: GRCz11Chromosome: 16
    Type Name Annotation Method Has Havana Data Length (nt) Analysis
    mRNA chrnb2-201 (1) Ensembl 6,596 nt
    mRNA chrnb2-203 (1) Ensembl 6,862 nt
    mRNA chrnb2-204 (1) Ensembl 6,551 nt
    mRNA chrnb2b-202 (1) Ensembl 1,685 nt
    1 - 4 of 4
    Interactions and Pathways
    No data available
    Antibodies
    No data available
    Plasmids
    No data available
    Constructs
    No data available
    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACCH211-105C13
    1 - 1 of 1
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanCHRNB21
    Phylogenetic tree (1)
    Conserved genome location (synteny) (2)
    Amino acid sequence comparison (2)
    MouseChrnb23
    Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Phylogenetic tree (1)
    Citations
    1 - 10 of 11
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