Gene
loxl3a
- ID
- ZDB-GENE-070818-2
- Name
- lysyl oxidase-like 3a
- Symbol
- loxl3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable fibronectin binding activity and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; fibronectin fibril organization; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in cytoplasm and nucleus. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in head mesenchyme; mesenchyme; and notochord. Human ortholog(s) of this gene implicated in myopia. Orthologous to human LOXL3 (lysyl oxidase like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22418 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 1 of 1
Show
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myopia 28, autosomal recessive | 619781 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Lysyl oxidase | Lysyl oxidase, conserved site | Lysyl oxidase-like protein | SRCR domain | SRCR-like domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:X1WBP7 | InterPro | ||||||
| UniProtKB:F1RD85 | InterPro | 739 | |||||
| UniProtKB:A0A5H1ZRI5 | InterPro | 791 | |||||
| UniProtKB:A0AB32T381 | InterPro | 734 |
1 - 4 of 4
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
loxl3a-201
(1)
|
Ensembl | 2,373 nt | ||
| mRNA |
loxl3a-202
(1)
|
Ensembl | 2,529 nt | ||
| mRNA |
loxl3a-203
(1)
|
Ensembl | 2,220 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-305J1 | ZFIN Curated Data | |
| Contained in | BAC | CH73-369O7 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199870 (1) | 2529 nt | ||
| Genomic | GenBank:BX511303 (1) | 190512 nt | ||
| Polypeptide | UniProtKB:A0A5H1ZRI5 (1) | 791 aa |
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- van Boxtel, A.L., Gansner, J.M., Hakvoort, H.W., Snell, H., Legler, J., and Gitlin, J.D. (2011) Lysyl oxidase-like 3b is Critical for Cartilage Maturation During Zebrafish Craniofacial Development. Matrix biology : journal of the International Society for Matrix Biology. 30(3):178-87
- Jovelin, R., Yan, Y.L., He, X., Catchen, J., Amores, A., Canestro, C., Yokoi, H., and Postlethwait, J.H. (2010) Evolution of developmental regulation in the vertebrate FgfD subfamily. Journal of experimental zoology. Part B, Molecular and developmental evolution. 314(1):33-56
- Gansner, J.M., Mendelsohn, B.A., Hultman, K.A., Johnson, S.L., and Gitlin, J.D. (2007) Essential role of lysyl oxidases in notochord development. Developmental Biology. 307(2):202-213
1 - 4 of 4
Show