Gene

adamts2a

ID
ZDB-GENE-070816-3
Name
ADAM metallopeptidase with thrombospondin type 1 motif, 2a
Symbol
adamts2a Nomenclature History
Previous Names
  • ADAMTS2/3 (1)
  • adamts22
  • adamts2
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Brunet et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adamts2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ehlers-Danlos syndrome dermatosparaxis type Alliance Ehlers-Danlos syndrome, dermatosparaxis type 225410
Associated With adamts2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR010294 ADAMTS/ADAMTS-like, Spacer 1
Domain IPR010909 PLAC
Domain IPR041645 ADAMTS, cysteine-rich domain 2
Domain IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family IPR013273 ADAMTS/ADAMTS-like
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Domain Details Per Protein
Protein Length ADAMTS/ADAMTS-like ADAMTS/ADAMTS-like, cysteine-rich domain 3 ADAMTS/ADAMTS-like, Spacer 1 ADAMTS, cysteine-rich domain 2 Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide PLAC Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M9Q7A9 159
UniProtKB:A0A0R4ISF7 1295
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Huxley-Jones et al. (ZDB-PUB-070427-22) list ADAMTS2/3 as the ortholog of both human ADAMTS2 and ADAMTS3 based on amino acid sequence identity.
Citations