ZFIN is now using GRCz12tu for Genomic Data
Gene
adamtsl4
- ID
- ZDB-GENE-070815-2
- Name
- ADAMTS-like 4
- Symbol
- adamtsl4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within camera-type eye morphogenesis; cell-cell junction maintenance; and regulation of extracellular matrix assembly. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Used to study craniosynostosis and ectopia lentis with ectopia of pupil. Human ortholog(s) of this gene implicated in autosomal recessive isolated ectopia lentis 2 and ectopia lentis with ectopia of pupil. Orthologous to human ADAMTSL4 (ADAMTS like 4).
- Genome Resources
-
- Alliance (1)
- Gene:100333903 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tevar et al., 2025
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive isolated ectopia lentis 2 | Alliance | Ectopia lentis, isolated, autosomal recessive | 225100 |
| ectopia lentis with ectopia of pupil | Alliance | Ectopia lentis et pupillae | 225200 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| craniosynostosis | adamtsl4ucl6/ucl6 (AB) | standard conditions | Tevar et al., 2025 |
| ectopia lentis with ectopia of pupil | adamtsl4ucl6/ucl6 (AB) | standard conditions | Tevar et al., 2025 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | PLAC | Thrombospondin type-1 repeat superfamily | Thrombospondin type-1 (TSP1) repeat |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P832 | InterPro | 1047 | ||||||
| UniProtKB:A0A8M9NZG4 | InterPro | 1089 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance