Gene
adam22
- ID
- ZDB-GENE-070810-1
- Name
- ADAM metallopeptidase domain 22
- Symbol
- adam22 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6446 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14978 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19148 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36238 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adam22 | Qin et al., 2024 | |
| CRISPR2-adam22 | Qin et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 61 | Alliance | Developmental and epileptic encephalopathy 61 | 617933 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAM, cysteine-rich domain | Disintegrin, conserved site | Disintegrin domain | Disintegrin domain superfamily | EGF-like domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | Reprolysin domain, adamalysin-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AJF6 | InterPro | 949 | |||||||||
| UniProtKB:A0A8M9P8I9 | InterPro | 871 | |||||||||
| UniProtKB:A0A8M9PDU9 | InterPro | 978 | |||||||||
| UniProtKB:F1QF43 | InterPro | 918 | |||||||||
| UniProtKB:A0A8M3ATT0 | InterPro | 737 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adam22-201
(1)
|
Ensembl | 4,159 nt | ||
| mRNA |
adam22-202
(1)
|
Ensembl | 1,440 nt | ||
| mRNA |
adam22-203
(1)
|
Ensembl | 1,561 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-246D10 | ||
| Has Artifact | cDNA | MGC:173905 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001111085 (1) | 1772 nt | ||
| Genomic | GenBank:CR848685 (1) | 149329 nt | ||
| Polypeptide | UniProtKB:A0A8M9PDU9 (1) | 978 aa |
- Comparative Orthology
- Alliance
- Qin, W., Liang, F., Lin, S.J., Petree, C., Huang, K., Zhang, Y., Li, L., Varshney, P., Mourrain, P., Liu, Y., Varshney, G.K. (2024) ABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish. Nature communications. 15:56135613
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
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