Gene

adam22

ID
ZDB-GENE-070810-1
Name
ADAM metallopeptidase domain 22
Symbol
adam22 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adam22 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 61 Alliance Developmental and epileptic encephalopathy 61 617933
Associated With adam22 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018358 Disintegrin, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR001762 Disintegrin domain
Domain IPR002870 Peptidase M12B, propeptide
Domain IPR006586 ADAM, cysteine-rich domain
Domain IPR013111 EGF-like domain, extracellular
Domain IPR034027 Reprolysin domain, adamalysin-type
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036436 Disintegrin domain superfamily
Domain Details Per Protein
Protein Length ADAM, cysteine-rich domain Disintegrin, conserved site Disintegrin domain Disintegrin domain superfamily EGF-like domain EGF-like domain, extracellular Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin Peptidase M12B, propeptide Reprolysin domain, adamalysin-type
UniProtKB:A0A8M3AJF6 949
UniProtKB:A0A8M9P8I9 871
UniProtKB:A0A8M9PDU9 978
UniProtKB:F1QF43 918
UniProtKB:A0A8M3ATT0 737
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adam22-201 (1) Ensembl 4,159 nt
mRNA adam22-202 (1) Ensembl 1,440 nt
mRNA adam22-203 (1) Ensembl 1,561 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations