Gene
adam22
- ID
- ZDB-GENE-070810-1
- Name
- ADAM metallopeptidase domain 22
- Symbol
- adam22 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 61 | Alliance | Developmental and epileptic encephalopathy 61 | 617933 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018358 | Disintegrin, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR001762 | Disintegrin domain |
| Domain | IPR002870 | Peptidase M12B, propeptide |
| Domain | IPR006586 | ADAM, cysteine-rich domain |
| Domain | IPR034027 | Reprolysin domain, adamalysin-type |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036436 | Disintegrin domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAM, cysteine-rich domain | Disintegrin, conserved site | Disintegrin domain | Disintegrin domain superfamily | EGF-like domain | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | Reprolysin domain, adamalysin-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AJF6 | InterPro | 949 | |||||||||
| UniProtKB:A0A8M9P8I9 | InterPro | 871 | |||||||||
| UniProtKB:A0A8M9PDU9 | InterPro | 978 | |||||||||
| UniProtKB:F1QF43 | InterPro | 918 | |||||||||
| UniProtKB:A0A8M3ATT0 | InterPro | 737 | |||||||||
| UniProtKB:A0AB32TAI8 | InterPro | 947 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adam22-201
(1)
|
Ensembl | 4,159 nt | ||
| mRNA |
adam22-202
(1)
|
Ensembl | 1,440 nt | ||
| mRNA |
adam22-203
(1)
|
Ensembl | 1,561 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance