Gene

adam12b

ID

ZDB-GENE-070809-1

Name

ADAM metallopeptidase domain 12b

Symbol

adam12b Nomenclature History

Previous Names

adam12
adam12a (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in osteoarthritis. Is expressed in heart tube; intermediate cell mass of mesoderm; lateral plate mesoderm; midbrain; and pharyngeal arch cartilage. Orthologous to human ADAM12 (ADAM metallopeptidase domain 12).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Tokumasu et al., 2016

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam12b Human Ortholog

No data available

Associated With adam12b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018358	Disintegrin, conserved site
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR006586	ADAM, cysteine-rich domain
Domain	IPR034027	Reprolysin domain, adamalysin-type
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily

Domain Details Per Protein

Protein	Length	ADAM, cysteine-rich domain	Disintegrin, conserved site	Disintegrin domain	Disintegrin domain superfamily	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	Reprolysin domain, adamalysin-type
UniProtKB:A0A8M6YVV0 InterPro	937
UniProtKB:A0A0R4INJ8 InterPro	941

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	adam12-202 (1) Ensembl	Ensembl	894 nt	Select Tool
mRNA	adam12-201 (1) Ensembl	Ensembl	4,497 nt	Select Tool
mRNA	adam12-203 (1) Ensembl	Ensembl	3,205 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations