Gene

qdprb.2

ID

ZDB-GENE-070720-19

Name

quinoid dihydropteridine reductase b, tandem duplicate 2

Symbol

qdprb.2 Nomenclature History

Previous Names

dhprbb (1)
qdprb2
zgc:171799

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With qdprb.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
BH4-deficient hyperphenylalaninemia C	Alliance	Hyperphenylalaninemia, BH4-deficient, C	261630

Associated With qdprb.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001509	NAD-dependent epimerase/dehydratase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	NAD-dependent epimerase/dehydratase	NAD(P)-binding domain superfamily
UniProtKB:E9QFJ2 InterPro	257
UniProtKB:A0A2R8PY37 InterPro	257
UniProtKB:A0A8M3B0J5 InterPro	292
UniProtKB:F1REK5 InterPro	257
UniProtKB:A7MC04 InterPro	257