Gene
ephb2a
- ID
- ZDB-GENE-070713-2
- Name
- eph receptor B2a
- Symbol
- ephb2a Nomenclature History
- Previous Names
-
- ephb2 (1)
- si:ch73-160e9.1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within blood vessel development; convergent extension; and ephrin receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in dorsal aorta; optic cup; pronephric glomerular capillary; retina; and somite. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001090 | Ephrin receptor ligand binding domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR027936 | Ephrin receptor, transmembrane domain |
| Family | IPR016257 | Ephrin receptor type-A /type-B |
| Family | IPR050449 | Ephrin receptor tyrosine kinases |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase ephrin type A/B receptor-like | Tyrosine-protein kinase, receptor class V, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QKD8
|
999 | |||||||||||||||||||
|
UniProtKB:A0A8M9QA50
|
291 | |||||||||||||||||||
|
UniProtKB:A0A8M3ANP6
|
996 | |||||||||||||||||||
|
UniProtKB:A0A8M9PL45
|
999 | |||||||||||||||||||
|
UniProtKB:A0A8M9PWU2
|
996 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ephb2a-201
(1)
|
Ensembl | 6,435 nt | ||
| mRNA |
ephb2a-202
(1)
|
Ensembl | 2,929 nt | ||
| mRNA |
ephb2a-203
(1)
|
Ensembl | 1,444 nt |
Interactions and Pathways
Plasmids
No data available