Gene

ephb2a

ID

ZDB-GENE-070713-2

Name

eph receptor B2a

Symbol

ephb2a Nomenclature History

Previous Names

ephb2 (1)
si:ch73-160e9.1

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have transmembrane-ephrin receptor activity. Involved in blood vessel development; convergent extension; and ephrin receptor signaling pathway. Predicted to localize to integral component of plasma membrane; neuron projection; and receptor complex. Is expressed in dorsal aorta; optic cup; pronephric glomerular capillary; retina; and somite. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2).

Genome Resources

Note

None

Expression

All Expression Data

11 figures from 9 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ephb2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Bleeding disorder, platelet-type, 22	618462
		{Prostate cancer/brain cancer susceptibility, somatic}	603688

Associated With ephb2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001090	Ephrin receptor ligand binding domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR003961	Fibronectin type III
Domain	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR027936	Ephrin receptor, transmembrane domain
Family	IPR016257	Ephrin receptor type-A /type-B
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily