Gene

ephb2a

ID
ZDB-GENE-070713-2
Name
eph receptor B2a
Symbol
ephb2a Nomenclature History
Previous Names
  • ephb2 (1)
  • si:ch73-160e9.1
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Is predicted to enable transmembrane-ephrin receptor activity. Involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within blood vessel development; convergent extension; and ephrin receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in dorsal aorta; optic cup; pronephric glomerular capillary; retina; and somite. Human ortholog(s) of this gene implicated in blood platelet disease. Orthologous to human EPHB2 (EPH receptor B2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ephb2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Bleeding disorder, platelet-type, 22 618462
{Prostate cancer/brain cancer susceptibility, somatic} 603688
Associated With ephb2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001090 Ephrin receptor ligand binding domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR003961 Fibronectin type III
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR027936 Ephrin receptor, transmembrane domain
Family IPR016257 Ephrin receptor type-A /type-B
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Ephrin receptor ligand binding domain Ephrin receptor, transmembrane domain Ephrin receptor type-A /type-B Fibronectin type III Fibronectin type III superfamily Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase ephrin type A/B receptor-like Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:A0A2R8Q936 291
UniProtKB:F1RCR4 1015
UniProtKB:A0A2R8QJW7 394
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations