Gene

daam2

ID

ZDB-GENE-070709-1

Name

dishevelled associated activator of morphogenesis 2

Symbol

daam2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable actin binding activity. Predicted to be involved in negative regulation of oligodendrocyte differentiation; positive regulation of canonical Wnt signaling pathway; and regulation of non-canonical Wnt signaling pathway. Predicted to act upstream of or within actin cytoskeleton organization. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With daam2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Nephrotic syndrome, type 24	619263

Associated With daam2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010472	Formin, FH3 domain
Domain	IPR010473	Formin, GTPase-binding domain
Domain	IPR014767	Diaphanous autoregulatory (DAD) domain
Domain	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain	IPR015425	Formin, FH2 domain
Family	IPR051425	Formin Homology
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR042201	Formin, FH2 domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	Diaphanous autoregulatory (DAD) domain	Formin, FH2 domain	Formin, FH2 domain superfamily	Formin, FH3 domain	Formin, GTPase-binding domain	Formin Homology	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:A0A8M1PZ97 InterPro	1095

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	daam2-201 (1) Ensembl	Ensembl	1,301 nt	Select Tool ZFIN BLAST
mRNA	daam2-202 (1) Ensembl	Ensembl	3,270 nt	Select Tool ZFIN BLAST
mRNA	daam2-203 (1) Ensembl	Ensembl	3,087 nt	Select Tool ZFIN BLAST
mRNA	daam2-204 (1) Ensembl	Ensembl	3,057 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations