Gene
adamtsl2
- ID
- ZDB-GENE-070705-558
- Name
- ADAMTS-like 2
- Symbol
- adamtsl2 Nomenclature History
- Previous Names
-
- ADAMTSL2a (1)
- si:rp71-31m18.1
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adamtsl2 | Trubiroha et al., 2018 | |
| CRISPR2-adamtsl2 | Trubiroha et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| geleophysic dysplasia 1 | Alliance | Geleophysic dysplasia 1 | 231050 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q4Y9 | InterPro | 1012 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamtsl2-201
(1)
|
Ensembl | 6,772 nt | ||
| mRNA |
adamtsl2-202
(1)
|
Ensembl | 396 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-31M18 | ZFIN Curated Data | |
| Contained in | BAC | RP71-39F17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021476679 (1) | |||
| Genomic | GenBank:BX119981 (1) | 158974 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q4Y9 (1) | 1012 aa |
- Qiu, W., Fang, M., Magnuson, J.T., Greer, J.B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., Schlenk, D. (2020) Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring. Journal of hazardous materials. 399:123009
- Trubiroha, A., Gillotay, P., Giusti, N., Gacquer, D., Libert, F., Lefort, A., Haerlingen, B., De Deken, X., Opitz, R., Costagliola, S. (2018) A Rapid CRISPR/Cas-based Mutagenesis Assay in Zebrafish for Identification of Genes Involved in Thyroid Morphogenesis and Function. Scientific Reports. 8:5647
- Huxley-Jones, J., Clarke, T.K., Beck, C., Toubaris, G., Robertson, D.L., and Boot-Handford, R.P. (2007) The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evolutionary Biology. 7(1):63
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