Gene

wasf1

ID
ZDB-GENE-070705-555
Name
WASP family member 1
Symbol
wasf1 Nomenclature History
Previous Names
  • si:dkeyp-88f5.5
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be located in several cellular components, including anchoring junction; cytoskeleton; and synapse. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium. Orthologous to human WASF1 (WASP family member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sw107Allele with one delinsUnknownUnknownCRISPR
1 - 1 of 1
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-wasf1Luo et al., 2022
CRISPR2-wasf1Luo et al., 2022
1 - 2 of 2
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Human Disease
Associated With wasf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with absent language and variable seizures 618707
1 - 1 of 1
Associated With wasf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003124 WH2 domain
Family IPR028288 SCAR/WAVE family
1 - 2 of 2
Domain Details Per Protein
Protein Additional Resources Length SCAR/WAVE family WH2 domain
UniProtKB:A0A8M1Q749 InterPro 540
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 20
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA wasf1-201 (1) Ensembl 1,305 nt
mRNA wasf1-202 (1) Ensembl 1,476 nt
mRNA wasf1-203 (1) Ensembl 1,056 nt
mRNA wasf1-204 (1) Ensembl 1,497 nt
1 - 4 of 4
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEYP-88F5ZFIN Curated Data
1 - 1 of 1
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanWASF16
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseWasf110
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations