Gene
wasf1
- ID
- ZDB-GENE-070705-555
- Name
- WASP family member 1
- Symbol
- wasf1 Nomenclature History
- Previous Names
-
- si:dkeyp-88f5.5
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of Arp2/3 complex-mediated actin nucleation. Predicted to be located in several cellular components, including anchoring junction; cytoskeleton; and synapse. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium. Orthologous to human WASF1 (WASP family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sw107 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-wasf1 | Luo et al., 2022 | |
| CRISPR2-wasf1 | Luo et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with absent language and variable seizures | 618707 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | SCAR/WAVE family | WH2 domain |
|---|---|---|---|---|
| UniProtKB:A0A8M1Q749 | InterPro | 540 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-88F5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001335766 (1) | 1024 nt | ||
| Genomic | GenBank:CR545462 (1) | 199482 nt | ||
| Polypeptide | UniProtKB:A0A8M1Q749 (1) | 540 aa |
- Wang, Y.S., Chen, Y.T., Wu, C.Y. (2023) Functional characterization of stap2b in zebrafish vascular development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e23053e23053
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Luo, Z., Shi, J., Pandey, P., Ruan, Z.R., Sevdali, M., Bu, Y., Lu, Y., Du, S., Chen, E.H. (2022) The cellular architecture and molecular determinants of the zebrafish fusogenic synapse. Developmental Cell. 57(13):1582-1597.e6
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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