Gene

adamts12

ID
ZDB-GENE-070705-471
Name
ADAM metallopeptidase with thrombospondin type 1 motif, 12
Symbol
adamts12 Nomenclature History
Previous Names
  • si:dkey-43l20.2
  • unm_sa1731
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Brunet et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adamts12 Human Ortholog
No data available
Associated With adamts12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001590 Peptidase M12B, ADAM/reprolysin
Domain IPR006586 ADAM, cysteine-rich domain
Domain IPR010294 ADAMTS/ADAMTS-like, Spacer 1
Domain IPR010909 PLAC
Domain IPR041645 ADAMTS, cysteine-rich domain 2
Domain IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3
Family IPR013273 ADAMTS/ADAMTS-like
Family IPR050439 ADAMTS and ADAMTS-like
Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
Domain Details Per Protein
Protein Additional Resources Length ADAM, cysteine-rich domain ADAMTS/ADAMTS-like ADAMTS/ADAMTS-like, cysteine-rich domain 3 ADAMTS/ADAMTS-like, Spacer 1 ADAMTS and ADAMTS-like ADAMTS, cysteine-rich domain 2 Metallopeptidase, catalytic domain superfamily Peptidase M12B, ADAM/reprolysin PLAC Thrombospondin type-1 (TSP1) repeat Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0AB32TPW6 InterPro 1228
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA adamts12-201 (1) Ensembl 8,713 nt
mRNA adamts12-202 (1) Ensembl 656 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations