Gene
adamts12
- ID
- ZDB-GENE-070705-471
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 12
- Symbol
- adamts12 Nomenclature History
- Previous Names
-
- si:dkey-43l20.2
- unm_sa1731
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brunet et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
| Domain | IPR006586 | ADAM, cysteine-rich domain |
| Domain | IPR010294 | ADAMTS/ADAMTS-like, Spacer 1 |
| Domain | IPR010909 | PLAC |
| Domain | IPR041645 | ADAMTS, cysteine-rich domain 2 |
| Domain | IPR045371 | ADAMTS/ADAMTS-like, cysteine-rich domain 3 |
| Family | IPR013273 | ADAMTS/ADAMTS-like |
| Family | IPR050439 | ADAMTS and ADAMTS-like |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | ADAM, cysteine-rich domain | ADAMTS/ADAMTS-like | ADAMTS/ADAMTS-like, cysteine-rich domain 3 | ADAMTS/ADAMTS-like, Spacer 1 | ADAMTS and ADAMTS-like | ADAMTS, cysteine-rich domain 2 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB32TPW6 | InterPro | 1228 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adamts12-201
(1)
|
Ensembl | 8,713 nt | ||
| mRNA |
adamts12-202
(1)
|
Ensembl | 656 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance