Gene

arhgef18b

ID

ZDB-GENE-070705-462

Name

rho/rac guanine nucleotide exchange factor (GEF) 18b

Symbol

arhgef18b Nomenclature History

Previous Names

si:dkey-38o13.1

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Involved in cilium movement. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Choksi et al., 2014

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Choksi et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef18b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Retinitis pigmentosa 78	617433

Associated With arhgef18b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR041020	ARHGEF1-like, PH domain
Family	IPR051632	Rho guanine nucleotide exchange factor
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily

Domain Details Per Protein

Protein	Length	ARHGEF1-like, PH domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	Rho guanine nucleotide exchange factor
UniProtKB:A0A8N7TD86 InterPro	1059
UniProtKB:F1QCK8 InterPro	1012

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef18b-201 (1) Ensembl	Ensembl	3,224 nt	Select Tool ZFIN BLAST
mRNA	arhgef18b-202 (1) Ensembl	Ensembl	3,618 nt	Select Tool
mRNA	arhgef18b-203 (1) Ensembl	Ensembl	3,302 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations